Structure: MGF (Mechano Growth Factor) is a natural splice variant of IGF-1, expressed in response to muscle damage. PEG MGF is a modified version of MGF where a polyethylene glycol (PEG) group is attached to improve its properties.
Stability: MGF has a short half-life, making it less stable and quickly broken down in the body. PEGylation increases stability by shielding the peptide from enzymatic degradation.
Half-Life and Bioavailability: MGF has a very short half-life of just minutes, whereas PEG-MGF boasts a prolonged half-life, potentially lasting hours, allowing for improved bioavailability and systemic effects.
Function: Both peptides promote muscle repair and growth by activating satellite cells and protein synthesis. PEG-MGF’s longer half-life enables it to circulate systemically, targeting more muscles, while MGF works mainly at the localized site of expression.
Applications:
- MGF: Ideal for targeted repair but limited by its rapid breakdown.
- PEG-MGF: Superior for systemic muscle recovery and broader therapeutic potential due to extended activity.
Each peptide’s usage depends on specific goals like localized treatment (MGF) or systemic effects (PEG-MGF).
MGF peptide is typically delivered in a lyophilized solid form and should be stored in a freezer at or below -20°C for long term storage. Once reconstituted, the peptide solution should be stored at 4°C and used within a short term, usually 24 hours. MGF has not yet been approved for human consumption. MGF is for laboratory purposes only.